In this sequel, Las Vegas performer Deloris Van Cartier (Whoopi Goldberg) is surprised by a visit from her nun friends, including Sister Mary Patrick (Kathy Najimy) and Sister Mary Lazarus (Mary Wickes). It appears Deloris is needed in her nun guise as Sister Mary Clarence to help teach music to teens at a troubled school in hopes of keeping the facility from closing at the hands of Mr. Crisp (James Coburn), a callous administrator. Can Deloris shape the rowdy kids into a real choir?