Reformed outlaw Glyn McLyntock (James Stewart) has become a guide for farmers headed to Oregon. When he rescues thief Emerson Cole (Arthur Kennedy) from execution, Cole joins him on the journey. Once the settlers arrive, they discover that a trader who was supposed to send them provisions is now trying to scam them. After McLyntock and Cole travel to Portland to forcibly retrieve the supplies, Cole betrays McLyntock and steals the goods himself. McLyntock pursues, ready for battle.