Melanie Parker (Michelle Pfeiffer) is an architect who needs to give a very important presentation. Jack Taylor (George Clooney) is a reporter looking to land a big scoop for his story. Both are single parents whose children, Sammy (Alex D. Linz) and Maggie (Mae Whitman), respectively, miss the bus for a field trip. Left with their kids on such a hectic day, Parker and Taylor decide to put aside their bickering and juggle baby-sitting duties, but the rambunctious children don't make it easy.