Wayne Wilderson

Dismembered remains are discovered in several mailing boxes at a dead letter office, and the Jeffersonian team identifies the victim as an employee of a local Ship ’n’ Print, where the staff recently split the winnings of a lottery prize. The team uncovers a complicated love triangle between two married employees and the victim, and while motive points to the husband (guest star Ben Savage), a critical clue leads them to solve the crime definitively. Meanwhile, Booth’s grandfather (guest star Ralph Waite) breaks some unexpected news, and Special Agent Genny Shaw (guest star Tina Majorino) learns the importance of teamwork.

An outbreak of a sexually transmitted disease affects several members of the hospital staff, prompting Chief Webber to call a meeting. Meanwhile, the chief reluctantly confides to Dr. (Derek) Shepherd about his own medical concerns; Izzie and Cristina are worried by a patient's wife and daughter who are at odds over his care; Burke treats Bill, a college buddy whose medical diagnosis raises some questions regarding his wife's actions; and, just as Meredith and Derek grow more intimate, a bombshell is dropped.

Sheldon and Amy try hanging out as friends when they spend Thanksgiving together at the Aquarium. Meanwhile, Howard reluctantly agrees to volunteer at the soup kitchen with Bernadette, Raj and Emily, while Penny discovers that Leonard knows more about her than she thought.

Grissom and Nick investigate the death of a book restorer; Catherine and Sara examine the wreckage of a train crash.

Grissom investigates the death of a jogger; Catherine tries to determine the cause of death of a little girl on a carnival ride.

When Sheldon gets sick and has to spend a few days in the hospital he turns into the world’s worst patient and his behavior takes a toll on everyone. Also Missy gets a taste of what life would be like without her twin.