Jack Merrill

Cristina's encounter with a former nurse, now a patient at Seattle Grace, changes her forever; Derek and Meredith treat a construction worker who has miraculously survived an injury but is now faced with tough decisions about his future; and a patient recognizes Izzie from a lingerie ad, which makes her the subject of hospital gossip.

An outbreak of a sexually transmitted disease affects several members of the hospital staff, prompting Chief Webber to call a meeting. Meanwhile, the chief reluctantly confides to Dr. (Derek) Shepherd about his own medical concerns; Izzie and Cristina are worried by a patient's wife and daughter who are at odds over his care; Burke treats Bill, a college buddy whose medical diagnosis raises some questions regarding his wife's actions; and, just as Meredith and Derek grow more intimate, a bombshell is dropped.

Mr. Big tells Carrie he will never marry again. After a harsh dumping, Samantha tries to turn 'The Turtle' (an investor with bad breath) into a Helmut Lang-wearing catch...but realizes he's still just The Turtle. Meanwhile, Miranda introduces Charlotte to 'The Rabbit' (a vibrator), which turns Charlotte into a recluse.

Caleb forces Kirsten to terminate Julie. Sandy and Kirsten question taking in Ryan. When Ryan and Luke ally to protect Marissa from Oliver, she discovers the truth about him.

Emily must rely on help from an unlikely source after her biggest takedown goes awry; Victoria attempts to secure her independence.

Don and his team look into the murder of a young woman in an up-and-coming actor's Hollywood Hills mansion.