Mary Joy

Addison gets a job offer away from Seattle Grace; Burke continues to have reservations about marrying Cristina; Susan returns to the hospital after feeling ill following the surgery.

Addison takes temporary leave from Seattle Grace and makes a road trip to Los Angeles in order to visit some old friends from medical school. As Meredith continues to bond with her stepmother, Susan, Cristina reluctantly plans her wedding with the assistance of her mother, Helen, and Burke's mother, Mama Jane. Meanwhile, Derek must perform emergency surgery on Ava/Jane Doe, as Alex continues his unfailing bedside manner with her.

A psychotic patient threatens Abby; Dr. Weaver suspects a woman poisoned her own baby; Dr. Romano continues to make rash judgments.

Galavan and Penguin join forces with a dangerous family in Gotham. Then, as the rivalry between the Waynes and the Galavans resurfaces, Gordon struggles to maintain order in the city.

President Meyer travels to Iran, where an American reporter is being detained; Dan is wooed by a lobbyist; Doyle stands in for the president at an event; Kent's polling may cause trouble for Selina.