Troy Landry, his son Chase, legendary gator hunter Bruce Mitchell, and big fish wrangler Zak Bagby team up with professional snake hunter Bill Booth, the men dive into the underbelly of the Everglades to capture and remove the sinister beasts.

The swampers venture into the foreboding Everglades Triangle; Bruce, Zak and Bill hunt near a mysterious abandoned rocket silo, while Troy and Chase scour a cattle ranch for one of the world's deadliest snakes: the African Rock Python.

Hunters face a terrifying reality: the invasion is bigger than they anticipated; with their backs against the wall, Troy, Chase and Bill call upon trackers and thermal drones to get a leg up on the snakes.

As the hunters face their final week in the Everglades, Troy and Chase protect a remote community from an aggressive gang of alligators; then, they join forces to track down a deadly hybrid python.

Troy Landry, his son Chase and snake expert Bill Booth track serpents into a breeding ground known as Deer Haven; veteran swamper Bruce Mitchell and invasive species hunter Zak Catchem take on the legendary Skunk Ape Alley.

As the hunting season heats up, Troy, Chase and Bill dive into deep water to catch pythons but could be in over their heads.