Miguel (Javier Bardem), a Spanish doctor, puts himself in harm's way to deliver medical treatment to the victims of military uprisings. Wren (Charlize Theron) is the spokesperson for an organization that funds medical assistance for impoverished nations the world over. They meet in Liberia, where Wren is immediately impressed with Miguel's selflessness, medical skill and charm. They begin a torrid affair, one they must learn to balance with their important work.