In 1979, a Long Island town falls into a panic when Charlie Bragg (Timothy Hutton), a hapless husband and father, is diagnosed with Lyme Disease. His wife, Melissa (Cynthia Nixon), takes a job working for their womanizing next-door neighbor, Mickey Bartlett (Alec Baldwin), whose philandering ways are no secret to his wife (Jill Hennessy). As tensions rise, the Braggs' teenage daughter, Adrianna (Emma Roberts), and the Bartletts' teenage son, Scott (Rory Culkin), try to maintain their sanity.