Linda Eve Miller

As Cristina tries to recover, she proves to be a very difficult patient, and a visit from her mother doesn't improve her demeanor any. And Meredith's mother, Dr. Ellis Grey, has the hospital staff running in circles. Jeremiah, a cystic fibrosis patient, could benefit from Dr. Addison Shepherd's medical knowledge, but her involvement in his surgery could delay her highly anticipated departure from Seattle Grace Hospital, leaving Meredith and Derek's relationship hanging in the balance.

Cristina tries to help Preston cope with his hand tremor, Izzie attempts to return to the hospital for the first time since she quit the program, Alex deals with a patient who has a long history of injuries, and George and Callie's relationship moves forward.

George and Izzie test their romantic chemistry; Derek asks for more than a physical connection with Meredith; Mark develops a crush on a fellow surgeon; Callie finds her role as chief resident jeopardized.

Halloween is full of surprises for the doctors of Seattle Grace; Alex receives an unexpected visit from a former patient; Meredith thinks her mother's ashes are haunting her; a surgeon Cristina admires snubs her.

George's skill level dazzles the new interns; Meredith halfheartedly helps Lexie with her first emergency patient.

Through Lexie, Meredith tries to get Derek interested in a patient's rare brain tumor; Callie ends up being annoyed when Mark and Arizona finally form a friendship; Teddy and Alex look into alternative surgeries for a superficial patient.