Amie Donegan

Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson.

When Cody and Carrie catch the flu, Zack has to take care of them. The entire staff of the Tipton Hotel goes crazy trying to impress Mr. Moseby for Employee of the Month.