S2, E26: Izzie and George attend to Denny as the pressure increases to find him a new heart, Cristina suddenly finds herself in charge of an ER, and Derek grapples with the realization that the life of a friend is in his hands. In the second hour, "Losing My Religion," Richard goes into interrogation mode about a patient’s condition, Callie confronts George about his feelings for her, and Meredith and Derek meet about Doc.