Alixandrée Antoine

After learning about Richard's drinking problem, Derek confronts him; Izzie returns, hoping to reconcile with Alex; tensions run high for Teddy, Cristina and Owen in the aftermath of Cristina's startling confession.

As part of their training, Seattle Grace's residents are put in charge; the attending surgeons compete for a million dollar grant.

Derek and the attendings go out to celebrate when he gets the grant he needs for his clinical trial; Meredith and Alex must fend for themselves during the night shift.

Unsettling news motivates Derek and Meredith to take preventive steps for their children's future; Syrian doctors come to the hospital for a crash course in basic surgical skills; April decides to tell Matthew the truth.

Owen puts the residents through a rigorous trauma certification drill; Cristina is left alone to monitor an ill lung transplant patient.

A small plane crash in Seattle causes multiple casualties and brings back horrible memories for the doctors, especially Meredith and Arizona. Meanwhile, friction between Owen and Amelia makes for an uncomfortable working situation for Stephanie.