Meredith and Derek get one last shot at success in their clinical trial; the surgeons work together to free a boy from a block of cement; Izzie helps Alex care for Rebecca; Lexie uncovers critical information about George's status as an intern.
When Violet files for joint custody of Lucas, Pete fights back, forcing friends and co-workers to choose sides.
Jack feels torn between Emily and a new woman in his life; Louise and Nolan bring Southern charm to East Hampton.
The team searches for a serial killer along the Appalachian Trail in rural Virginia.