Cristina won't let herself get excited when she is nominated for a Harper Avery award; Alex thinks about making a change; Callie and Derek work with a machine that recognizes emotions.
Jackson must deliver bad news to the doctors; Derek's sister visits; Richard surprises Catherine in Boston; Bailey makes a risky decision about her research.
Meredith helps Cristina draft an acceptance speech; Derek feels the weight of his responsibilities; April and Jackson are at odds about children and religion; Callie and Arizona try to reconnect.
The doctors are exposed to flu-infected patients; Derek prepares to give a speech; a new doctor gives Alex a glimpse into an alternative medical practice.