Earl (Jason Lee, "Almost Famous," "Chasing Amy") has taken one too many wrong turns on the highway of life. However, a twist of fate turns his life into a tailspin of life-renewing events. Earl wins a small lottery, and, after an epiphany, he is determined to transform his good fortune into a life-changing event as he sets out to right all the wrongs from his past. Joining Earl along his quest to cleanse his karma are a few dim-witted friends: hapless brother Randy (Ethan Suplee, "Cold Mountain") and the very sexy Catalina (Nadine Velazquez, "The Bold and the Beautiful"). Even Darnell (Eddie Steeples, "Torque"), the owner of the Crab Shack where Earl drinks beer, offers his support. But it's Earl's ex-wife Joy (Jaime Pressly, "Not Another Teen Movie") who won't lift a finger to help unless there's something in it for her.

Earl decides that one way he can balance the karmic scales is by quitting smoking, but this proves to be more difficult than he imagined.

Earl tries to amend for an unethical sports wager on a high-school game that deprived his brother Randy of a chance to score a touchdown.

While atoning for stealing from a convenience store, Earl sees Natalie (Beth Riesgraf), a woman he broke up with by faking his death.

Earl's old friend, Ralph (Giovanni Ribisi), gets out of prison and kidnaps Randy, hoping he will reveal where to find Earl's money.

Earl tries to help Joy's former nemesis and her daughter win a beauty pageant to make up for breaking a special figurine only awarded to pageant winners.