The Incredible Dr. Pol

In the premiere episode, we meet Dr. Jan Pol, who, along with his wife Diane, runs thriving veterinary clinic located in Central Michigan's farm country.

Dr. Pol, assisted by his son Charles, is faced with several difficult cases, including a police dog who is lethargic and losing weight for no obvious reason and an aggressive terrier whose leg seems broken yet is normal according to his x-ray. If that weren't enough, Dr. Pol must also attend to several emergency farm calls including treating a cow with a twisted stomach and one down on the ground with a prolapsed uterus. This caseload could be a struggle for vets half his age, but Dr. Pol takes it all in stride. Meanwhile, Charles, who's visiting from LA, gains a renewed respect for his dad as he watches him navigate the emotional and physical demands of working as a farm vet.

An Australian Sheepdog is brought to the clinic after eating a dead deer carcass which is poisonous to dogs. Then, Dr. Pol and son his Charles must wrestle a flock of sheep in order to take blood samples to test for OPP - Ovine Progressive Pneumonia, a progressive disease that is incurable and highly contagious. Back at the clinic, Dr. Brenda tests a lump in a Doberman's mammary gland and concludes it is pre-cancerous. Will she be able to successfully remove it to save the dog's life?

A Boer goat has lost 50 pounds after refusing to eat and Dr. Pol suspects a parasite is to blame. A French bulldog is brought into the clinic after being hit by a car. Dr. Pol must keep the dog overnight to x-ray him and to surgically remove his injured eye. And, Dr. Pol is praised by a local family for treating their English Springer Spaniel who has mange, a contagious skin diseases caused by parasitic mites.

A dog really does eat homework; a horse rapidly loses weight; a tornado warning forces all the animals and staff into the basement.

Spring fever at the clinic; emergencies and triple-booked appointments are the order of the day.