S6, E15: Raphael (guest star LANETTE WARE) launches an attack on Castiel and his allies, sending a particularly frightening angelic hitman (guest star CARLOS SANZ) after Balthazar, Sam and Dean. In an effort to protect the brothers, Balthazar sends them to an alternate universe where they are the stars of a TV show called "Supernatural" and they are actors named "Jensen Ackles" and "Jared Padalecki." The brothers are confused when Castiel appears to be a tweet-happy actor named Misha Collins and Sam is married to Ruby (guest star GENEVIEVE CORTESE).