Building friendships often starts with people having common connections, and similarities associated with pain, fear, and everyday struggles are especially bonding. `Two in a Million' follows the emotional journeys of people who suffer from some of the world's most unusual disorders. In each episode, two people who share the same medical condition meet and spend one week together, relating hardships and incredible triumphs, visiting world-renowned doctors, and finding answers to important questions. The connections they make are powerful beyond imagination.