Best friends Smurfette (Demi Lovato), Brainy (Danny Pudi), Clumsy (Jack McBrayer) and Hefty (Joe Manganiello) use a special map that guides them through the Forbidden Forest, an enchanted wonderland that's filled with magical creatures. Their adventure leads them on a course to discover the biggest secret in Smurf history as they race against time and the evil wizard Gargamel (Rainn Wilson) to find a mysterious village.