Manolo Cardona's career in acting began with his roles in various films like the dramatic adaptation "Rosario Tijeras" (2005) with Flora Martinez, the dramatic adaptation "My Brother's Wife" (2006) with Angélica Aragón and "Beverly Hills Chihuahua" (2008) with Drew Barrymore. He continued to work steadily in film throughout the early 2000s and the 2010s, appearing in "Undertow" (2010), "El cartel de los sapos" (2012) and the Sharon Stone thriller "The Mule" (2013). He also appeared in the drama "Fort Bliss" (2014) with Michelle Monaghan. He also played parts in television during these years, including roles in "Covert Affairs" (USA, 2009-2014) and "Reign" (CW, 2013-). Most recently, Cardona appeared in "Narcos" (2014-).