As Daisy and the team try to protect inhumans, a shocking truth is revealed about S.H.I.E.L.D.'s biggest enemy; with Fitz's help, Simmons recovers information that could get them back through the portal.
When a new inhuman is discovered, Coulson and the team have an encounter with another organization seeking powered people; Fitz goes to extreme measures to determine how to get Simmons back.
The stakes get higher as May and Hunter pursue Ward and Hydra; Coulson thinks the ATCU could be keeping a big secret.
Coulson and the team search for the Inhuman who is killing other Inhumans; May worries Hunter's mission to bring down Ward is becoming too personal.
The S.H.I.E.L.D. team tries to prove that fate is not fixed after Daisy is horrified by a glimpse of the future.