While well known for her voice-over work, Cartwright also appeared in the flesh in several projects. Due to the youthful appearance of the blonde actress, early in her career she often played characters much younger than her real age. She made her film debut (playing a young girl) in the "It's A Good Life" segment of 1983's "Twilight Zone the Movie." Another notable role came two years later in the historical adventure "Flesh + Blood" (1985) starring Jennifer Jason Leigh. In 1998, she returned to the big screen with a small role as a secretary in "Godzilla." More prolific was Cartwright's small screen work, with appearance in several TV-movies and as a guest star on a number of series. In 1982, she made her debut in the title role of a young girl wrongly institutionalized in the CBS TV biopic "Marian Rose White." While she was cast primarily for her look, Cartwright handled the role more than capably. She followed up with a steady stream of telefilms while also continuing her plentiful voice work. In 1987, a new chapter began in Cartwright's professional career when she was tapped to provide the voice of perennial ten-year old Bart Simpson, a sharp tongued mischief maker for animated segments of "The Tracey Ullman Show." From shorts on the show to its own long-running series on Fox, "The Simpsons" kept Cartwright in the public ear if not the public eye.