Peter Birkenhead

Bree's forced to handle catering for Bob and Lee's wedding by herself when Katherine bails out; Gaby gets a call from Ellie; Julie finds out about her acceptance to Princeton, but Susan doesn't want her to go.

When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems. Meanwhile, as Dr. Webber recovers from brain surgery, it seems that his wife (guest starring Loretta Devine as Mrs. Webber) has some concerns about the state of their marriage.

Susan's mother-in-law visits; Carlos and Gaby find out their tenant has a dark secret; a war erupts between Bree and Edie.

House must diagnose a man who became sick and experienced a breathing attack while role-playing in the bedroom, but all tests keep returning normal.

Nate and Brenda find comfort; Ruth has a surprising self-assessment; Federico becomes suspicious of Vanessa; a former client sues.

Claire finds Billy's newfound lust for life seductive; visions of an early trauma haunt George; Vanessa encourages Rico to mingle; Nate shares a tragic bond with Maggie.