The apparently comatose Michael Myers (George P. Wilbur) is being transferred from one hospital to another, but he wakes up when the ambulance crew talk about his surviving niece, Jamie (Danielle Harris). After slaughtering his attendants, Myers sets out to find his one living relative who is, fortunately, being cared for by a kind and resourceful foster sister named Rachel (Ellie Cornell). Meanwhile, the ever-cautious Dr. Loomis (Donald Pleasence) remains on the killer's path.