Mac Brandt

"Grey's Anatomy's" three-episode story arc continues with a part two that will challenge the interns of Seattle Grace -- and "Grey's" fans as well -- like never before.

Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.

While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith and Derek's wedding; Callie's father visits; Owen seeks help with his PTSD.

Derek and Meredith get ready for their wedding; college students injured in a car accident are admitted to the ER; Izzie starts experiencing familiar symptoms.

Nora prepares to prove herself to Gallo and considers confessing to Ian; Jimmy and Crank's actions have devastating consequences; Jess considers taking matters into her own hands.

Patrick Jane, Agent Lisbon and CBI agents investigate the murder of a successful criminal attorney whose only client is one of California’s most dangerous and powerful motorcycle gangs.