The doctors must treat a 25-year-old runner who is suffering from severe swelling; two 16-year-old cancer patients are dating; Dr. Shaun Murphy and Dr. Carly Lever work toward intimacy.
Riley tries to make new friends in high school but everyone acts less friendly than she expects.
Coulson uncovers Gen. Hale's true agenda; it could be the end of the world if S.H.I.E.L.D. doesn't help her.
Lainey has a difficult choice regarding her relationship with Barry and her friendship with CB; Coach Mellor and Julie are put in a tough parenting position when Toby is invited to prom as a freshman by a senior.