Holmes and Watson discover a connection between a clown's murder and the creation of a weaponized virus; Bell's new love interest's ex targets him.
Vincent moves into a seedy hotel and contemplates an offer from mob capo Rudy Pipilo; Bobby hopes to take advantage of Vincent's new connections; filmmaking intrigues Candy; C.C. shows Lori the benefits of having a pimp; Larry feels unsettled.
Frank is left with minimal information to find a missing boy when a conflicted priest who could help won't break the seal of confession. Also, Danny and Baez investigate the death of a prominent New York City socialite with a secret life, and Jamie and Eddie attend a wedding together.
While accompanying Alison on a college campus tour, Elizabeth is ambushed by a group protesting a Chilean mining operation; Henry, Jane and Jose Campos try to locate Jibral Disah's third wife, Hijriyyah.