In the season three premiere Mary (Zoe Perry) worries about Sheldon's mental health after Dr. Sturgis experiences a nervous breakdown.
While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith and Derek's wedding; Callie's father visits; Owen seeks help with his PTSD.
Maisy Gibbons' (Sharon Lawrence) secret life intersects with Bree's; Gabrielle's predicament worsens; Susan plans to take her relationship with Mike to the next level; Lynette is suspicious of her new nanny (Marla Sokoloff).
Susan looks forward to a romantic date with Mike until she learns a surprising fact about her favorite plumber; Lynette's cranky old neighbor (Kathryn Joosten) accuses the Scavo twins of thievery.
Harsh words between Ted and Lily nearly ruin the gang's Christmas.