Owen is faced with tough decisions as Seattle Grace spirals toward financial ruin; Jo and Alex try to save an infant's life; April turns to Jackson for dating advice.
The FBI profilers race against time to save a family trapped in a real life house of horrors and stop the perpetrator before he strikes again.
Anna and Summer are upset with Seth. Julie has love problems. Sandy helps Jimmy with legal issues. Kirsten's indiscretion is exposed. Ryan and Luke form an unexpected alliance.
Ryan is glad Theresa will stay in Newport. Julie and Luke's secret affair is threatened when Jimmy sees them. When Anna plans to move back to Pittsburgh, Seth tries to stop her.
Julie has a memorable wedding shower. Theresa returns, and when Ryan finds out why, he is shocked. Seth gets the chance to meet Summer's father, but it doesn't go very well.
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