A young autistic surgeon (Freddie Highmore) who relocates from Wyoming to California to complete his medical training relies on his top-notch skills to disprove his colleagues’ skepticism.
Dr. Shaun Murphy's attention to detail complicates his first day; Dr. Claire Browne learns a valuable lesson about honesty when confronted with a difficult diagnosis for her patient.
Dr. Melendez and Dr. Unger discover their patient isn't being completely honest with them; Dr. Browne must learn to communicate with Dr. Murphy as they race back to the hospital with a donated organ.
Legalities abound when a husband and wife have to make a life-changing decision about their unborn child; Dr. Shaun Murphy struggles to adjust to his new environment at home and takes a huge step forward with his colleagues.
Dr. Shaun Murphy encounters a young patient who looks eerily similar to his deceased brother; Shaun discovers his parents hid his diagnosis from him; the team must find the cause of their patients' increasingly severe allergic reactions.