The BAU team travels to San Francisco to investigate the murders of several homeless men and teams up with a separate group of BAU operatives who are working another case they think is connected.
Chimney relives his evolution as a firefighter, looking back at how he joined Station 118 and became the firefighter and paramedic he is today.
Hondo and his old DEA friend join forces to locate the secretive leader of a drug-smuggling ring. Jessica puts her new law enforcement initiatives into action.
When the team gets too close to the truth about Wo Fat and his associates, the criminal mastermind retaliates by trying to destroy the team. They've always played by their own rules, but the Governor can no longer protect them.
Hondo's life and career are threatened when his off-the-books surveillance of his godson's kidnapper is discovered. Street has trouble acclimating to his newly paroled mother.