A gas tanker explodes on a highway, resulting in multiple injuries; Jo and Meredith try to help a frantic woman, whose child has a mysterious illness; Alex is forced to work with Jo's boyfriend.
In the wake of the disastrous Meade/Slater nuptials, Wilhelmina plots her next moves and Betty tries to sort things with Daniel.
Henry reluctantly agrees to go on a double date with Betty and an unlikely couple - Hilda and Gio. Meanwhile, Wilhelmina's attempt to change her image as the queen of mean fails miserably after she tangles with America's most beloved golden girl.
Revealing the story of Robbie's transition into Ghost Rider. Also, the lives of Coulson and the team hang in the balance.
Coulson is unaware of a dark secret May is hiding, even as the two grow closer; Aida is determined to find the Darkhold.
