The team investigate a family that is robbed and the young daughter is raped after being overcome by nitrous oxide.
Dr Manning and Dr Choi must deliver a baby under dire circumstances, and Dr Rhodes and Dr Bekker argue about treating a boy with a chronic disease. As Dr Halstead and April deal with an uncomfortable situation, Goodwin and Maggie deal with a lawsuit.
After a 10-year-old boy is admitted to the hospital, Dr Manning and Dr Halstead disagree on how to handle the boy's parents.
Choi and April consider calling social services when they suspect that a patient is being abused, while Manning and Halstead have a disagreement.
Marcus, Tomas and Mother Bernadette race against the clock to stop the demon, and the Rance family is pulled into the conflict; the church's enemies become more aggressive as the pope's visit nears; Angela faces someone from her past.
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