The BAU investigates a group of suspects with a pack mentality who are randomly selecting their victims in the nation's capital and murdering them for the thrill of it.
Despite Dean's directive to forget about looking for a cure for the Mark of Cain, Sam continues to do research. Dean suspects Sam is hiding something but decides to focus on a new murder case where they run into Cole. The three team up and learn a Khan worm is infecting men and turning them into murderers. Unfortunately, the worm makes its way into Cole.
Crowley notices Dean is becoming more and more aggressive. Dean tells him that’s the side effect of being a demon, but Crowley knows it’s something more - the Mark of Cain needs to be fed. Meanwhile, Sam is captured by Cole (guest star Travis Aaron Wade), an angry man who blames Dean for his father’s death years ago and wants revenge. Cole tortures Sam, hoping he’ll tell him where Dean is hiding. Hannah (guest star Erica Carroll) sees how weak Castiel is becoming as his grace continues to fade, so she makes a bold choice and asks Metatron for help.
When Sydney is taken into custody by the NSC, Jack and Vaughn have no choice but to ally themselves with Sloane to rescue her, but with only hours to spare before she is forced to undergo radical surgery to recover her memories, they must put together an extraction team, headed by freelance operative Brill. Lauren faces an impossible choice - to side with either the NSC or with her husband.
A shift that yields a high bodycount just needs a victim to arrive on the autopsy table after dying from natural causes to complete a full house of causes of death.
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