A notorious street artist becomes a suspect when corpses are used in macabre graffiti art in Detroit; Dr. Lewis tries to balance work and her relationship with her fiance.
The team investigates a shipwreck carrying exotic animals that now threaten the native wildlife on Oahu; Alex sustains a career-ending injury; Kai asks a fish and wildlife agent out on a date.
A fireworks explosion at a local concert sends patients streaming into the emergency room; Syd returns from Afghanistan and struggles to get back to normal.
A victim unexpectedly awakes on Rosie's autopsy table, throwing the team into a world full of people who go to extremes to keep their secrets.