Tommy wants to lose weight so he can marry his fiancée and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

Dominic's life is falling apart due to his food addiction. Over 600 pounds and living in a van with his brother, Dominic decides to leave California for Texas.

At 24 years old and over 600 lbs, Megan lives at home with her mum, who cooks for her since Megan can't do much on her own. Megan must travel to Houston to meet Dr Now and change her eating habit or her life may end before it ever begins.

Single mum Leneatha works incredibly hard at the hospital. However, her dangerous eating addiction is putting her life at risk, can Dr Now help save her life?

24-year-old Ashley's only source of comfort is food and fake friendships. Soon, she learns she can't lie to Dr Now like she does with everyone else.

With bonus scenes - At nearly 1,000-lbs, Samantha is dangerously close to dying. To make matters worse, she's paid to eat by making videos online.

Thederick has become housebound from eating, and for ten years, he has only gone outside to greet the ice cream man. After a recent hospital scare, Dr Now tries to help.

Featuring the life of Carrie, who weighs over 600lbs. Through her weight-loss journey, she attempts to drop the pounds and change her lifestyle to survive.

Morbidly obese patients strive to lose weight through diet and gastric bypass surgery with the help of Dr. Younan Nowzaradan.

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body. Now, the only way to get her life back is to leave it behind to start a new one with Dr. Now's help in Houston.

Kenae' was already big before her weight gain took off after the death of her beloved mother. Refusing to deal with the pain, Kenae' turned to food to fill the void. But she'll be reunited with her mum soon if the denial continues.