Meet small town pharmacist Doug Varney (Sam Rockwell). Soft in the middle, henpecked by his Type-A wife (Michelle Monaghan), Doug is sleepwalking through life, wishing things could change but doing nothing about it. He arrives at his place of employment, Bishop's Pharmacy, on a beautiful square in downtown Woodbury, where he's taking over the business from his father in law. Walter Bishop (Ken Howard), is a gruff know-it-all who doesn't think much of Doug, when he thinks of him at all. Doug does what a local pharmacist does, filling prescriptions, consulting with patients and trying to manage his two dimwitted staffers - checkout girl Janet (Jenn Harris) and delivery guy Noah (Ben Schwartz). But Doug's whole life changes when he's forced to make a delivery run and ends up at the magnificent home of Elizabeth Roberts (Olivia Wilde). A lonely, beautiful trophy wife, Elizabeth is trapped in her surroundings, much as Doug has been. Despite being from different worlds, there's instantaneous chemistry between them and when she drunkenly kisses Doug during their first meeting, a whole new avenue opens up for him.