Halstead goes undercover to investigate the death of a teen who ran away from a treatment centre for troubled girls.
Dr Choi and April believe that a patient's family may be abusing her; Dr Manning and Dr Halsted look after a family struggling with a premature baby.
Dr Manning and Dr Choi are forced to deliver a baby under dire circumstances; Dr Rhodes and Dr Bekker disagree about treating a boy with a chronic disease.
Hakeem leaves the altar, and a rooftop fight leads to a tragic fall. Lucious uses his streaming service to pursue his music legacy and clashes with Tariq, who leads a federal task force to investigate him.
Jamal partners with Angelo Dubois to host a summit for gun violence awareness, Lucious tries to win over Cookie, Hakeem and Shine start to record new songs together, and Andre gets into trouble with the police.