When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems.
A fuel tanker explodes on a highway, resulting in multiple injuries; Jo and Meredith try to help a frantic woman, whose child has a mysterious illness; Alex is forced to work with Jo's boyfriend.
The doctors put together a fundraising gala; Bailey must face several difficult patients; Shane and Stephanie take care of the busy ER on their own; Alex opens up to Jo.
Givens gets caught in a tense hostage negotiation with a dangerous prisoner, Ava is threatened by the Crowder clan and Winona has a run-in with a sinister associate of her husband.
The doctors prepare for a super storm headed for Seattle; as Owen becomes closer to Ethan, his desire to be a parent gets stronger; Meredith and her baby are put in danger.