Luke and Manny have their first day of high school, and Claire returns to the workforce. Meanwhile, Mitch juggles an important meeting and Lily's first day of preschool.
The Red Cell team must track down a suspect who is kidnapping young mothers; Beth discovers why this particular case hits close to home for Mick.
Sam, Dean, and Castiel call on Rowena to help keep the evil souls at bay, and get an unexpected assist from Ketch.
The boys continue collecting paraphernalia that will help them open the rift and save their family; they are led to a 1920s Men of Letters bunker where they encounter an other-dimensional god.
Joss finds herself in the middle when Savi and Harry argue about selling their home; Toni continues to annoy Savi; April discovers that she has to throw an over-the-top party for the parents at Lucy's expensive school.