Born David Abaire in South Boston, MA, he was the son of working class parents; his mother was a factory employee, while his father sold produce at a fruit market in the Boston suburb of Chelsea. After a stint in public school, he earned a six-year scholarship to the prestigious Milton Academy prep school, where he developed an interest in theater, as well as his unique perspective of being an outsider in an established and alien environment. He wrote some of his earliest plays as part of the school's tradition of staging work by students. Theater became his focus at Sarah Lawrence College, where he met his wife, actress Christine Lindsay, and assumed her surname. From 1996 to 1998, Lindsay-Abaire studied under such established dramatists as Marsha Norman and Christopher Durang as part of a playwriting program at Juilliard.After graduation, he moved to New York City, where he worked at Dance Theater Workshop while continuing to write plays. Some of his work was eventually produced off-off Broadway before his breakthrough came in 1999 with "Fuddy Mears," a screwball comedy about a woman who, upon waking each morning, discovers she has no memory of the prior day. Owing as much of a debt to the stage comedies of Moss and Hart as to screen legends Preston Sturges and the Marx Brothers, "Fuddy Mirrors" - the title came from a character, left paralyzed by a stroke, who attempted to say "funny mirrors" - was a wildly popular show during its original New York run, and in numerous productions across the United States. It was soon followed by 2000's "Wonders of the World," which starred Sarah Jessica Parker as a woman who flees her imploded marriage to find her way at Niagara Falls. In 2005, he made his debut as a screenwriter with "Robots" (2005), an animated feature for 20th Century Fox that performed modestly well at the box office.In 2006, Lindsay-Abaire shifted gears with "Rabbit Hole," a drama with comic touches about a mother who learns to contend with the death of her son. A major triumph in the 2006-07 Broadway season, it received the Pulitzer Prize for Drama, and earned star Cynthia Nixon a Tony Award for her fearless performance as the mother. The success of the play opened doors to major projects for Lindsay-Abaire, including the book for "High Fidelity," a 2006 musical based on the novel by Nick Hornby, and the book and lyrics for "Shrek the Musical" (2008). The former was a disappointment, while the latter netted numerous Tony Award nominations, including a nod to Lindsay-Abaire for Best Book of a Musical.In 2007, he penned his second screenplay, an adaptation of the fantasy novel "Inkheart" by Cornelia Funke. The film, with Brendan Fraser as a man with the ability to make stories come to life by reading them, was an underwhelming performer in its initial release, but positive international and DVD sales ultimately transformed it into a hit. That same year, he and Gary Ross were hired to provide rewriters of James Vanderbilt's script for "Spider-Man 4;" however, the collapse of the project put an end to Lindsay-Abaire's participation in the series, and Vanderbilt was recalled to write the script for the 2012 reboot. In 2010, Lindsay-Abaire received an Independent Spirit Award nomination for penning the screenplay for John Cameron Mitchell's film version of "Rabbit Hole." The picture, which starred Nicole Kidman and Aaron Eckhart, received rave reviews in its limited theatrical release, which expanded to a wider release in January 2011.