The agents' first case takes them to Oregon to investigate the unsolved murders of several high-school classmates. `Spooky' Mulder believes they have been experimented on by aliens.
A computer hacker's access to secret government files may threaten the lives of agents Mulder and Scully.
Suspicion arises that someone at the FBI, possibly Asst Dir Skinner, is responsible for Scully's contraction of a fatal disease.
The future of the X-Files is endangered as Scully lingers near death, while the Cigarette-Smoking Man comes forward with an offer to save her life.
While investigating the death of a local star football player, Officer McCann falls for a suspect who is infected with AIDS.