The team are called to shut down a campus in order to create a profile for a killer, but they have doubts about the main suspect after taking them into custody.
In the biggest case of his career, Marshall faces off with his archenemy, Brad; the gang remembers delinquent moments from their teenage years.
Kate and Toby spend time with baby Jack; Beth and Randall must adjust to the changes in their lives; Zoe and Kevin attempt to better their relationship.
The wait is over as Conrad and Nic welcome the arrival of their baby girl; Raptor's life begins to fall apart and he is forced to turn to Cain for help; Devon and Bell work together on a complicated surgery that may allow them to save multiple lives.
The inner workings of the hospital are seen through the eyes of Dr Cuddy.