When Manny and Luke babysit Lily so the adults can have a day to themselves, things go awry. Claire is convinced the boys are throwing a party.
Jane and Kim investigate the murder of five DEA agents in Corpus Christi, and Jane goes on a date with a beautiful woman associated with the case.
Meredith learns Amelia's true feelings about Seattle; Bailey deals with the consequences of her actions; Callie receives terrible news; news of a firing causes panic among the residents.
Cristina considers her future at the hospital; Amelia and Derek collaborate on a tough surgery involving conjoined twins; Jo takes on too many cases at once; Stephanie stumbles on the truth about Bailey's case.
The doctors are exposed to flu-infected patients; Derek prepares to give a speech; a new doctor gives Alex a glimpse into an alternative medical practice.