After a plane crashes in Atlanta, Devon is overcome by guilt at the thought that he could have prevented it; Adaku returns to ask Mina a big favor; Conrad and Nic consider risking it all to investigate a drug that might be linked to Jessie's death.
Conrad attempts to surprise Nick with a Valentine's Day dinner; Mina and Devon try to find out how their neighbour passed away; Kit offers dating advice to a patient.
A particularly nasty flu season turns out to be masking an outbreak of an infectious disease; Chastain rushes to diagnose and quarantine infected patients; Conrad isn't sure that Nic is ready to take the next step.
Conrad works to diagnose a young woman after she is admitted due to extreme night terrors; Devon tries to survive his first Halloween in the emergency room.
After being terminated, Conrad has difficulty figuring out his next step and distracts himself by accompanying a patient on a zero-gravity adventure; Cain puts the doctors on a commission-based pay system; Bell's company gets its big break.