Alex treats a patient whose religious beliefs place her life in jeopardy. Meredith wants to know more about Derek, and Izzie ponders contacting her estranged mother.
Naomi seeks Fife's help with William's experimental treatment for ALS; Violet and Amelia treat a woman with a brain tumour; Sheldon goes after Charlotte's affections.
Buffy invents an ingenious plan to destroy the First.
Andrew uses a video camera to document a day in the life of Buffy and her friends, and the Sunnydale students turn into fire-breathing demons.
The Scoobies use a spell to transport Buffy into a shadow world, where she meets the men who created the first slayer. However, in order for her to return home, the gang must find and slay a ferocious demon.