Dr Devon Pravesh begins his first day as an intern and quickly learns the harsh realities of medical care. Meanwhile, resident Conrad Hawkins shows off his unconventional ways of treating patients.
When Padma's pregnancy takes a dangerous turn, the doctors come together to find a solution and turn to Ian to perform a miracle; Conrad makes a decision regarding his love life and Devon leads his own clinical trials at Chastain.
The staff are pushed to their limits with three concurrent surgeries; Conrad struggles with feeling jealousy when Nic requests Jude for an operation.
An attack by cybercriminals sends the hospital into a tailspin, and Kit must decide whether to pay the ransom; Conrad works on balancing life as a new dad; Devon and Leela debate taking the next step in their relationship.
Devon treats his first patient with a revolutionary medical fluid that doesn't go as planned; an overdosed John Doe is rushed to Chastain, leading Conrad straight into a much bigger scandal than he expected.