Mayor Tom Kane finds out he has a serious medical condition and tries to focus on the upcoming gubernatorial primary.

With a new, powerful entry in the political race, Kane and his people flex their political muscles to maintain their hold. A worried Meredith suspects her husband is keeping something from her.

Zajac's campaign gains momentum; Kane tries to adjust to his medical reality; Miller stumbles upon a story.

As Kane finds himself starting to lose control in both his personal and professional lives, his supporters begin to question their confidence in him.

Kane and his camp battle with the media to dominate the situation when long-buried information about the disposal of toxic waste near the airport comes to the surface via a mysterious blogger.

Kane takes a break from City Hall; Kitty is at an emotional impasse; Meredith seeks opportunities of her own.