The Tipton has an exhibition of South American artefacts. When Zack and Cody try to get a private viewing, they create havoc.
The twins are finding it hard to make friends at their new school, but do get on with the school geeks, Max and Tapeworm. When the rest of the kids find out Zack and Cody live in the hotel they suddenly want to hang out with them, but things get out of hand and the twins have to put a stop to it. They decide Max and Tapeworm are their only genuine new friends.
Zack and Cody go on a game show called `Risk it All'. Maddie gets annoyed with Moseby and lets off steam by writing an e-mail she doesn't intend to send, but London sends it by accident.
Zack and Cody try to nurse their mum, who has flu, but prove pretty useless at it. Competition is fierce for Employee of the Month when Moseby offers a big prize.
Zack and Cody take aptitude tests. Zack is told he'd make a good CEO, while Cody's best qualified to be a garbage collector! Meanwhile, Maddy saves a VIP's life.